Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy

• DOI: 10.1002/advs.202201703
• Publication Date: 2022-06-09T07:50:13Z
• Authors: Weiwei Zeng; Mian Yu; Ting Chen; Yuanqi Liu; Yunfei Yi; Chenyi Huang; Jia Tang; Hanyue Li; Meitong Ou; Tianqi Wang; Meiying Wu; Lin Mei
• Keywords: Polypyrrole

Nanozyme-based tumor catalytic therapy has attracted widespread attention in recent years, but its therapeutic outcome is drastically diminished by species of nanozyme, concentration substrate, pH value, and reaction temperature, etc. Herein, a novel Cu-doped polypyrrole nanozyme (CuP) with trienzyme-like activities, including catalase (CAT), glutathione peroxidase (GPx), (POD), first proposed straightforward one-step procedure, which can specifically promote O