Microneedle Patches with O2 Propellant for Deeply and Fast Delivering Photosensitizers: Towards Improved Photodynamic Therapy

• DOI: 10.1002/advs.202202591
• Publication Date: 2022-07-15T20:55:22Z
• Authors: Pei Liu; Yangxue Fu; Fulong Wei; Teng Ma; Jingli Ren; Zhanjun Xie; Shanzheng Wang; Jinjin Zhu; Lianbin Zhang; Juan Tao; Jintao Zhu
• Keywords: Phototoxicity; Penetration (warfare)

Abstract Photodynamic therapy (PDT) is an emerging technique for treating tumors. Especially, topical administration of photosensitizers (PSs) more favorable superficial tumor treatments with low systematic phototoxicity. Yet, ineffective migration PSs to targeted tissues and rapid consumption O 2 during PDT greatly limit their effects. Herein, PS‐loaded microneedle (MN) patches propellant a deeper faster transdermal delivery PS improved by embedding sodium percarbonate (SPC) into dissolving poly(vinyl pyrrolidone) MNs are presented. It shown that SPC in the can react surrounding fluid generate gaseous oxygen bubbles, forming vigorous flows thus enhancing chlorin e6 (Ce6) penetration both hydrogel models skin tissues. Reactive species (ROS) hypoxic breast cancer cells (4T1 cells) increased relief hypoxia vitro, Ce6‐loaded show excellent cell‐killing effect. Moreover, lower growth rate mass after 20‐d treatment tumor‐bearing mice model verify oxygen‐droved PS. This study demonstrates facile yet effective route MN treatment.