Versatile Hydrogel Dressing with Skin Adaptiveness and Mild Photothermal Antibacterial Activity for Methicillin‐Resistant Staphylococcus Aureus‐Infected Dynamic Wound Healing

• DOI: 10.1002/advs.202206585
• Publication Date: 2023-02-13T07:22:53Z
• Authors: Peng Zhao; Yu Zhang; Xiaoai Chen; Chang Xu; Jingzhe Guo; Meigui Deng; Xiongwei Qu; Pingsheng Huang; Zujian Feng; Jimin Zhang
• Keywords: Methicillin-Resistant Staphylococcus aureus; Wound Healing; Science; Q; Hydrogels; 02 engineering and technology; hydrogel dressing; Bandages; mild photothermal antibacterial; Anti-Bacterial Agents; MRSA infected wound healing; skin‐adaptiveness; 0210 nano-technology; Research Articles

Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use antibiotics for infected management. Hence, a versatile hydrogel (rGB/QCS/PDA-PAM) skin adaptiveness on dynamic wounds and mild photothermal is developed safe efficient treatment. Phenylboronic acid-functionalized graphene (rGB) oxadiazole-decorated quaternary carboxymethyl chitosan (QCS) are incorporated into polydopamine-polyacrylamide (PDA-PAM) network with multiple covalent noncovalent bonds, which conferred flexible mechanical properties, strong tissue adhesion excellent self-healing ability wounds. Moreover, glycocalyx-mimicking phenylboronic acid surface rGB enables specifically capture bacteria. The enhanced membrane permeability QCS bacterial vulnerability therapy（PTT）, demonstrated by PTT antibacteria against methicillin-resistant Staphylococcus aureus in vitro vivo at temperatures <49.6 °C. Consequently, demonstrate accelerated regeneration MRSA-infected vivo, an intact epidermis, abundant collagen deposition prominent angiogenesis. Therefore, rGB/QCS/PDA-PAM inherent has considerable potential treating drug-resistant