Design of Antioxidant Nanoparticle, which Selectively Locates and Scavenges Reactive Oxygen Species in the Gastrointestinal Tract, Increasing The Running Time of Mice

• DOI: 10.1002/advs.202301159
• Publication Date: 2023-08-01T12:14:16Z
• Authors: Takuto Toriumi; Hajime Ohmori; Yukio Nagasaki
• Keywords: reactive oxygen species; Lipopolysaccharides; 0301 basic medicine; Science; leaky gut; Q; exercise‐induced gastrointestinal syndrome; Antioxidants; Gastrointestinal Tract; Mice; 03 medical and health sciences; high‐intensity running; Animals; Nanoparticles; polymeric nanoparticle antioxidants; Reactive Oxygen Species; Research Articles

Excess reactive oxygen species (ROS) produced during strong or unfamiliar exercise cause exercise-induced gastrointestinal syndrome (EIGS), leading to poor health and decreased performance. The application of conventional antioxidants can neither ameliorate EIGS nor improve performance because their rapid elimination severe side effects on the mitochondria. Hence, a self-assembling nanoparticle-type antioxidant (RNP