Biomimetic Self‐Propelled Asymmetric Nanomotors for Cascade‐Targeted Treatment of Neurological Inflammation

• DOI: 10.1002/advs.202310211
• Publication Date: 2024-03-09T19:34:23Z
• Authors: Jiamin Ye; Yueyue Fan; Yaoguang She; Jiacheng Shi; Yiwen Yang; Xue Yuan; Ruiyan Li; Jingwen Han; Luntao Liu; Yong Kang; Xiaoyuan Ji
• Keywords: Penetration (warfare)

Abstract The precise targeted delivery of therapeutic agents to deep regions the brain is crucial for effective treatment various neurological diseases. However, achieving this goal challenging due presence blood‒brain barrier (BBB) and complex anatomy brain. Here, a biomimetic self‐propelled nanomotor with cascade targeting capacity developed inflammatory nanomotors are designed asymmetric structures mesoporous SiO 2 head multiple MnO tentacles. Macrophage membrane modification endows BBB penetration abilities catalyze degradation H O into , not only by reducing inflammation but also providing driving force penetration. Additionally, loaded curcumin, which actively regulates macrophage polarization from M1 M2 phenotype. All in vitro cell, organoid model, vivo animal experiments confirmed effectiveness targeting, penetration, anti‐inflammatory, nervous system function maintenance. Therefore, study introduces platform ability active