Programmable and Reversible Integrin‐Mediated Cell Adhesion Reveals Hysteresis in Actin Kinetics that Alters Subsequent Mechanotransduction (Adv. Sci. 35/2023)

• DOI: 10.1002/advs.202370244
• Publication Date: 2023-12-16T04:14:05Z
• Authors: Zheng Zhang; Hongyuan Zhu; Guoqing Zhao; Yunyi Miao; Lingzhu Zhao; Jinteng Feng; Huan Zhang; Run Miao; Lin Sun; Bin Gao; Wencheng Zhang; Zheng Wang; Jianfang Zhang; Ying Zhang; Hui Guo; Feng Xu; Tian Jian Lu; Guy M. Genin; Min Lin
• Keywords: Mechanotransduction

Mechanotransduction Article number 2302421 reports that cyclical adhesion can alter stem cell perception of extracellular microenvironment stiffness and thereby controls their mechanosensing fate commitment. Min Lin co-workers demonstrate through integrated modeling experiment accelerate cytoskeletal kinetics amplify nuclear mechanosensing. These findings have direct application for therapies broad implications study development.