Ti3C2Tx MXene‐Decorated 3D‐Printed Ceramic Scaffolds for Enhancing Osteogenesis by Spatiotemporally Orchestrating Inflammatory and Bone Repair Responses

• DOI: 10.1002/advs.202400229
• Publication Date: 2024-07-08T07:12:03Z
• Authors: Benzhao Huang; Shishuo Li; Shimin Dai; Xiaoqing Lu; Peng Wang; Xiao Li; Zhibo Zhao; Qian Wang; Ningbo Li; Jie Wen; Yifang Liu; Xin Wang; Zhentao Man; Wei Li; Bing Liu
• Keywords: Bone tissue; Macrophage polarization

Abstract Inflammatory responses play a central role in coordinating biomaterial‐mediated tissue regeneration. However, precise modulation of dynamic variations microenvironmental inflammation post‐implantation remains challenging. In this study, the traditional β‐tricalcium phosphate‐based scaffold is remodeled via ultrathin MXene‐Ti 3 C 2 decoration and Zn 2+ /Sr ion‐substitution, endowing with excellent reactive oxygen species‐scavenging ability, near‐infrared responsivity, enhanced mechanical properties. The induction mild hyperthermia around implant periodic irradiation facilitates spatiotemporal regulation inflammatory cytokines secreted by spectrum macrophage phenotypes. process initially amplifies pro‐inflammatory response, then accelerates M1‐to‐M2 polarization transition, yielding satisfactory pattern osteo‐immunomodulation during natural bone healing process. Later, sustained release ions gradual degradation 3D maintains favorable reparative M2‐dominated immunological microenvironment that supports new mineralization. Precise temporal immunoregulation intelligent enhances regeneration rat cranial defect model. This strategy paves way for application materials to guide toward outcome, making clinical treatment more predictable durable. findings also demonstrate irradiation‐derived promising method immunomodulation.