M6A‐mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8+ T cells and phagocytosis of macrophages

• DOI: 10.1002/advs.202400695
• Publication Date: 2024-07-09T19:49:28Z
• Authors: Qing Xi; Guangze Yang; Xue He; Hao Zhuang; Li Li; Bing Lin; Lingling Wang; Xianyang Wang; Chunqiang Fang; Qiurui Chen; Yongjie Yang; Zhaoan Yu; Hao Zhang; Wenqian Cai; Yan Li; Han Shen; Li Liu; Rongxin Zhang
• Keywords: antitumor response; 0301 basic medicine; LncRNA TUG1; Carcinoma, Hepatocellular; Hepatocellular carcinoma; Science; Macrophages; Q; Liver Neoplasms; CD47 Antigen; CD8-Positive T-Lymphocytes; Up-Regulation; Gene Expression Regulation, Neoplastic; Mice; Disease Models, Animal; 03 medical and health sciences; Phagocytosis; PD‐L1; Cell Line, Tumor; Animals; Humans; RNA, Long Noncoding; CD47; Research Article

Tumor immune evasion relies on the crosstalk between tumor cells and adaptive/innate cells. Immune checkpoints play critical roles in crosstalk, checkpoint inhibitors have achieved promising clinical effects. The long non-coding RNA taurine-upregulated gene 1 (TUG1) is upregulated hepatocellular carcinoma (HCC). However, how TUG1 effects are incompletely understood. Here, METTL3-mediated m