Preserving the Immune‐Privileged Niche of the Nucleus Pulposus: Safeguarding Intervertebral Discs from Degeneration after Discectomy with Synthetic Mucin Hydrogel Injection (Adv. Sci. 43/2024)

• DOI: 10.1002/advs.202470260
• Publication Date: 2024-11-20T19:20:06Z
• Authors: Huan Wang; Song Chen; Zhao Liu; Qingchen Meng; Rita Sobreiro‐Alm...; Ling Liu; Håvard Jostein Ha...; Jiaying Li; João F. Mano; Youzhi Hong; Thomas Crouzier; Hongji Yan; Bin Li

Mucin Hydrogels The study by Song Chen, Hongji Yan, Bin Li, and co‐workers unequivocally establishes the multifaceted utility of mucin hydrogels (Muc‐gels), showcasing their efficacy as both a physical shielding barrier and an immune‐isolating barrier for nucleus pulposus. This novel dual‐functionality presents a promising avenue for mitigating the recurrence rate of discectomy and impeding the progression of intervertebral disc degeneration. More details can be found in article number 2404496. [Image: see text]