High prevalence of anti‐prothrombin antibody in patients with deep vein thrombosis

• DOI: 10.1002/ajh.20124
• Publication Date: 2004-07-23T17:03:13Z
• Authors: Ken Ishikura; Hideo Wada; Yuko Kamikura; Kyouko Hattori; Toshiaki Fukuzawa; Norikazu Yamada; Masio Nakamura; Tsutomu Nobori; Takeshi Nakano
• Keywords: Lupus anticoagulant

Abstract The present study was designed to determine the prevalence of lupus anticoagulant (LA) antibody and several antibodies for antiphospholipid syndrome (APS) in patients with deep vein thrombosis (DVT)/pulmonary embolism (PE) ( n = 48), cerebral (CT, 30), systemic erythematosus (SLE, 22), idiopathic thrombocytopenic purpura (ITP, 30). presence examined by using respective ELISA kits. LA positive 38.6% DVT/PE, suggesting that is one most important risk factors DVT/PE. highest anti‐β 2 glycoprotein I (β GPI) IgG CT SLE, followed DVT, none ITP healthy volunteers (control, 40), it related thrombosis, particularly arterial thrombosis. anti‐prothrombin (aPT) control, especially venous (aPL) CT, but 0% control. On other hand, aPL IgM, anti‐annexin V IgG, IgM were both without they are not Our results indicated among anti‐phospholipid antibodies, sensitive marker APS while GPI aPT In particular, a significant Am. J. Hematol. 76:338–342, 2004. © 2004 Wiley‐Liss, Inc.