Recent Advances in the Asymmetric Total Synthesis of Camptothecin

• DOI: 10.1002/ajoc.202200515
• Publication Date: 2022-09-16T13:59:30Z
• Authors: Liangliang Song; Zhenwei Lv; Kui Zhang; Yile Wu; Erik V. Van der E...; Lingchao Cai
• Keywords: Camptothecin

Abstract During the past decades, a variety of routes for total synthesis camptothecin have been reported. Considering only ( S )‐camptothecin and analogues possessing ability to inhibit DNA enzyme topoisomerase I, numerous advances achieved asymmetric camptothecin, providing concise scalable approaches academic community pharmaceutical industry. This review outlines recent in is timely highly desirable rapid development this field. By constructing chiral tertiary alcohol center, diverse attractive strategies developed )‐camptothecin.