Age at Menarche and Its Potential Role in Early Detection of Hyperandrogenic Polycystic Ovary Syndrome

• DOI: 10.1002/ajpa.70046
• Publication Date: 2025-04-15T07:36:29Z
• Authors: C. Manthey; C. D. Lynn; C. Ocobock; T. J. Cepon‐Robins; A. Warrener

ABSTRACTObjectivesPolycystic ovary syndrome (PCOS) is a multifaceted heritable endocrine disorder that affects 4%–20% of females worldwide. Characterized by symptoms such as polycystic ovaries, anovulation, and hyperandrogenism, PCOS remains challenging to diagnose, particularly in its early stages. Research suggests that women with PCOS may experience earlier onset of menarche, but the mechanisms behind this association are not well understood. This study explores whether early menarche could serve as an effective diagnostic marker for PCOS.Materials and MethodsA survey was conducted with 95 adult women (ages 19–62), divided into two groups: women diagnosed with PCOS (49%, n = 47) and women without PCOS (51%, n = 48). Participants with PCOS self‐identified and were required to meet the Rotterdam Criteria for diagnosis. Notably, all self‐identified participants with PCOS exhibited the hyperandrogenic phenotype. Independent samples t‐tests and linear regression were used for data analysis.ResultsWomen with PCOS reached menarche an average of 1.8 years earlier than those without the condition (mean age 11.4 ± 1.6 years vs. 13.2 ± 1.2 years).DiscussionThese findings suggest that early menarche may be a promising, underexplored indicator of PCOS, offering a potential new avenue for earlier diagnosis of the condition. This could be particularly valuable, as PCOS is often not diagnosed until more classic symptoms, such as anovulation or hirsutism, emerge. Further research is needed to confirm these results and investigate the underlying mechanisms.