Vascular dysfunction in behavior‐variant frontotemporal dementia

• DOI: 10.1002/alz.072092
• Publication Date: 2023-12-25T06:05:50Z
• Authors: Min Chu; Deming Jiang; Miao Qu; Liyong Wu
• Keywords: Vascular dementia; Posterior cingulate; Leukoaraiosis

Abstract Background The vascular disturbance was recently found in a postmortem study of frontotemporal dementia (FTD), but whether dysfunction exists the early stage FTD remains elusive. aimed to explore there evidence and its relationship with central neurodegeneration clinical outcome. Method Twenty patients behavior (bvFTD) were enrolled underwent assessment peripheral plasma markers, positron emission tomography/magnetic resonance imaging, neuropsychological examinations. Group difference tested using student’s t‐test Mann‐Whitney U test. Partial correlation analysis implemented age sex as covariates association between neuroimaging, measures. Result All four factors including matrix metalloproteinases‐1(MMP‐1), metalloproteinases‐3 (MMP‐3), Osteopontin, pentraxin‐3 are increased group. level MMP‐1 negatively correlated gray matter metabolism prefrontal cortex (r = ‐0.5119, p 0.0210) anterior cingulate ‐0.4685, 0.0269). MMP‐3 temporal ‐0.4650, 0.0388). Pentraxin‐3 at sampling ‐0.5024, 0.0240) onset ‐0.5693, 0.0088). No other significant associations cytokines Conclusion bvFTD associated disease‐specific pattern, indicating perturbance BBB participation pathogenesis FTD. pathway might be promising target for future potential therapy.