Regional glymphatic abnormality in behavioral variant frontotemporal dementia

• DOI: 10.1002/alz.072222
• Publication Date: 2023-12-25T11:19:52Z
• Authors: Deming Jiang
• Keywords: Glymphatic System; Abnormality

Abstract Background The pattern of glymphatic inflow overlaps with the geographic behavioral variant frontotemporal dementia (bvFTD). function has not yet been explored in bvFTD. spatial correlation between regional and bvFTD remain unknown. Method A total 60 patients 61 age‐ sex‐matched healthy controls (HCs) were selected from two independent cohorts (discovery dataset Xuanwu Hospital replication Frontotemporal Lobar Degeneration Neuroimaging Initiative study). All participant underwent neuropsychological assessment. Glymphatic measures evaluated multimodal neuroimaging data, including choroid plexus volume, diffusion along perivascular space (DTI‐ALPS) index, coupling blood‐oxygen‐level‐dependent signals cerebrospinal fluid (BOLD‐CSF coupling), compared groups. To evaluate function, DTI‐ALPS BOLD‐CSF further divided into anterior, middle, posterior parts. BvFTD‐related metabolic was identified using covariance analysis based on [l8F]‐FDG‐PET. Result Patients showed higher volume ( P < 0.001); middle weaker anterior 0.05) than HCs after controlling for cortical gray matter both datasets. In discovery dataset, negatively associated expression bvFTD‐related r = ‐0.51, 0.029) positively related standardized uptake value ratios [l8F]‐FDG‐PET brain regions 0.44–0.60, range: 0.008–0.039). Worse is more severe global cognition decline, disease severity, neuropsychiatric symptoms. addition, 0.001), whereas lower 0.001). Conclusion Our findings reveal abnormal especially Regional dysfunction may contribute to pathogenesis