SEX EFFECTS ON THE QUALITY OF SLEEP IN DOWN SYNDROME

• DOI: 10.1002/alz.080585
• Publication Date: 2023-12-25T06:05:50Z
• Authors: Sandra Giménez; Susana Clos; Alexandre Bejanin; Maria Carmona‐Iragui; Javier Arranz; Bessy Benejam; Laura Videla; Susana Fernandez; Íñigo Rodríguez‐Baz; Isabel Barroeta; Alberto Lleo; Juan Fortea
• Keywords: Sleep; Sleep onset latency; Sleep Stages

Abstract Background Sex differences in biological factors, such as sleep, might contribute to sex dementia risk. Down’s syndrome (DS) is a genetically determined form of Alzheimer’s disease (AD), with disrupted sleep and high prevalence obstructive apnea (OSA). However, nocturnal adults DS have not been yet investigated. Thus, we aimed evaluate the effect on polysomnographic measures DS. Method Cross‐sectional study 187 from Down‐Alzheimer Barcelona Neuroimaging Initiative (DABNI) that underwent polysomnography study. Sleep macrostructure parameters i)sleep continuity [Total time(TST), efficiency(SE), Wake after onset(WASO), latency REM sleep], ii) NREM (phase N1, N2, N3) stages, minutes percentages, iii) respiratory determine presence OSA were evaluated. Chi‐squared Mann‐Whitney tests used test between categorical data, continuous variables, respectively. To effects parameters, performed ANCOVAs using measurements dependent sex, dementia, fixed effects, age covariate. Interactions subjects aso calculated Result Our cohort includes (57,2% females 42.8% males). was present 76,2% subjects, 22% had symptomatic AD (prodomal/demented) without significant both prevalences sexes(p = 0.23, p 0.08 respectively) (table 1). Females presented longer TST, WASO, (m), N2(m), N3(m), higher SE N3(%), decreased N1(%) compare males. These maintained correction. Results remain essentially similar when including statistical models. No interactions observed(Table2). Conclusion As general euploid population, better objective quality more deep than men. Further work needed investigate how can influence clinical biomarker profiles Down syndrome.