Accounting for lack of representation in dementia research: Generalizing KHANDLE study findings on the prevalence of cognitive impairment to the California older population

• DOI: 10.1002/alz.12522
• Publication Date: 2022-02-01T09:54:27Z
• Authors: Eleanor Hayes‐Larson; Taylor M. Mobley; Dan Mungas; Marissa J. Seamans; M. Maria Glymour; Paola Gilsanz; Charles DeCarli; Rachel A. Whitmer; Elizabeth Rose Ma...
• Keywords: Adult; Aging; Social Determinants of Health; Biological Psychology; Clinical Sciences; prevalence; racial/ethnic disparities; Clinical sciences; Neurodegenerative; Alzheimer's Disease; Basic Behavioral and Social Science; ethnic disparities; California; Healthy Aging; Life Change Events; 03 medical and health sciences; 0302 clinical medicine; Behavioral and Social Science; Acquired Cognitive Impairment; Prevalence; Psychology; Humans; Cognitive Dysfunction; Aetiology; generalizability; cognitive impairment; Biomedical and Clinical Sciences; Neurosciences; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Hispanic or Latino; racial; Brain Disorders; 3. Good health; Geriatrics; Neurological; Biological psychology; Dementia; Reduced Inequalities; 2.4 Surveillance and distribution; dementia

Most dementia studies are not population-representative; statistical tools can be applied to samples obtain critically-needed population-representative estimates, but yet widely used.We pooled data from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study California Behavioral Risk Factor Surveillance System (CA-BRFSS), a study. Using weights accounting for sociodemographic/health differences between KHANDLE CA-BRFSS, we estimated cognitive impairment prevalence age- sex-adjusted racial/ethnic inequalities in adults 65+ without prior diagnosis.After weighting KHANDLE, was 20.3% (95% confidence interval 17.8-23.0); unweighted 24.8% (23.1%-26.6%). Inequalities (larger prevalences) were observed among Black Asian groups versus whites.We used novel approach estimate inequalities. Such help estimates existing inform efforts reduce disparities.