Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology

• DOI: 10.1002/alz.13791
• Publication Date: 2024-04-04T21:53:28Z
• Authors: Kristiana Xhima; Julie Ottoy; Erin Gibson; Katherine Zukotynski; Christopher Scott; Ginelle J. Feliciano; Sabrina Adamo; Phillip H. Kuo; Michael J. Borrie; Howard Chertkow; Richard Frayne; Robert Laforce; Michael D. Nosewo...; Frank S. Prato; Demetrios J. Sahlas; Eric E. Smith; Vesna Sossi; Alexander Thiel; Jean‐Paul Soucy; Jean‐Claude Tardif; Maged Goubran; Sandra E. Black; Joel Ramirez
• Keywords: Male; Aged, 80 and over; Amyloid beta-Peptides; Neuroimaging; Hippocampus; White Matter; Magnetic Resonance Imaging; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Short Reports; Alzheimer Disease; Cerebral Small Vessel Diseases; Positron-Emission Tomography; Humans; Female; Atrophy; Aged

Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent on the pattern hippocampal atrophy, a key substrate memory impacted early extensively in dementia, remains poorly understood.