Neuron deficit in the white matter and subplate in periventricular leukomalacia

• DOI: 10.1002/ana.22612
• Publication Date: 2011-08-20T09:29:49Z
• Authors: Hannah C. Kinney; Robin L. Haynes; Gang Xu; Sarah E. Andiman; Rebecca D. Folkerth; Lynn A. Sleeper; Joseph J. Volpe
• Keywords: Subplate; Periventricular leukomalacia

The cellular basis of cognitive abnormalities in preterm infants with periventricular leukomalacia (PVL) is uncertain. One important possibility that damage to white matter and subplate neurons are critical the formation cerebral cortex occurs conjunction oligodendrocyte axonal injury PVL. We tested hypothesis overall density region significantly lower PVL cases compared non-PVL controls.We used a computer-based method for determination microtubule-associated protein 2-immunolabeled ventricular/subventricular region, matter, central controls.There were 5 subtypes subcortical neurons: granular, unipolar, bipolar, inverted pyramidal, multipolar. neuronal granular each 4 regions was 54 80% (p≤0.01) (n=15) controls adjusted age postmortem interval (n=10). densities multipolar, pyramidal did not differ between controls. No expressed markers glial immaturity (Tuj1, doublecortin, or NG2).These data suggest quantitative deficits susceptible occur distant from foci, including PVL, may contribute abnormal cortical dysfunction survivors.