Risk Profile of Patients with Spontaneous Cervical Artery Dissection

• DOI: 10.1002/ana.26717
• Publication Date: 2023-06-07T18:32:54Z
• Authors: Elisabetta Del Zotto; Mario Grassi; Marialuisa Zedde; Andrea Zini; Anna Bersano; Carlo Gandolfo; Giorgio Silvestrelli; Claudio Baracchini; Paolo Cerrato; Corrado Lodigiani; Simona Marcheselli; Maurizio Paciaroni; Alessandra Spalloni; Manuel Cappellari; Massimo Del Sette; Anna Cavallini; Enrico Maria Lotti; Maria Luisa Delod...; Mauro Gentile; Mauro Magoni; Marina Padroni; Cristiano Azzini; Maria Vittoria Ca...; Elisa Giorli; Massimiliano Braga; Paolo La Spina; Fabio Melis; Rossana Tassi; Valeria Terruso; Rocco Salvatore C...; Valeria Piras; Alessia Giossi; Sandro Sanguigni; Carla Zanferrari; Marina Mannino; Irene Colombo; Carlo Dallocchio; Patrizia Nencini; Valeria Bignamini; Alessandro Adami; Rita Bella; Rosario Pascarella; Zafer Keser; Alessandro Pezzini
• Keywords: Cervical Artery; Stroke

Objective Epidemiological data to characterize the individual risk profile of patients with spontaneous cervical artery dissection (sCeAD) are rather inconsistent. Methods and Results In setting Italian Project on Stroke in Young Adults Cervical Artery Dissection (IPSYS CeAD), we compared characteristics 1,468 sCeAD (mean age = 47.3 ± 11.3 years, men 56.7%) prospectively recruited at 39 centers those 2 control groups, composed (1) whose ischemic stroke was caused by mechanisms other than (non‐CeAD IS) selected from prospective IPSYS registry Brescia Registry (2) stroke‐free individuals staff members participating hospitals, matched 1:1:1 sex, age, race. Compared subjects, were more likely be hypertensive (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.37–1.98), have personal history migraine aura (OR 2.45, CI 1.74–3.34), without 2.67, 2.15–3.32), family vascular disease first‐degree relatives 1.69, 1.39–2.05), less diabetic 0.65, 0.47–0.91), hypercholesterolemic 0.75, 0.62–0.91), obese 0.41, 0.31–0.54). Migraine also associated 1.81, 1.47–2.22) comparison non‐CeAD IS. subgroup migraine, had higher frequency attacks take anti‐migraine preventive medications, especially beta‐blockers, groups. Interpretation The is influenced aura, factors, increases increasing attacks, seems reduced namely beta‐blockers. ANN NEUROL 2023;94:585–595