pH‐Responsive Nutraceutical–Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability

• DOI: 10.1002/ange.201208840
• Publication Date: 2013-01-16T21:40:45Z
• Authors: Rémy Guillet‐Nicolas; Amirali Popat; Jean‐Luc Bridot; Gregory Monteith; Shi Zhang Qiao; Freddy Kleitz
• Keywords: oral drug delivery; Ibuprofen; Nanoconjugates; 02 engineering and technology; Hydrogen-Ion Concentration; 1600 Chemistry; β-lactoglobulin; Silicon Dioxide; Colloidal stability; Drug Delivery Systems; Drug Stability; Microscopy, Electron, Transmission; Oral drug delivery; Nutraceutical; mesoporous silica; nutraceutical; Colloids; colloidal stability; 0210 nano-technology; Porosity; Mesoporous silica

Ein innovatives System für die orale Wirkstoffabgabe basierend auf der Funktionalisierung von Wirkstoff/Farbstoff-beladenen mesoporösen Siliciumdioxid-Nanopartikeln (MSNs) mit einem biologisch abbaubaren Nutrazeutikum (β-Lactoglobulin) wird vorgeschlagen. Die Konjugation des Nutrazeutikums verhindert nicht nur das Auslaugen Wirkstoffs/Farbstoffs unter sauren Bedingungen, sondern ermöglicht außerdem deren Freisetzung in gewünschten basischen Umgebungen (pH 7.4). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: The publisher is responsible content functionality of any Any queries content) directed corresponding author article.