Enantioselective Total Synthesis of (−)‐Lansai B and (+)‐Nocardioazines A and B

• DOI: 10.1002/ange.201402571
• Publication Date: 2014-04-28T13:27:06Z
• Authors: Haoxuan Wang; Sarah E. Reisman
• Keywords: heterocycles; Biological Products; Cycloaddition Reaction; Molecular Structure; natural products; Stereoisomerism; 540; 01 natural sciences; 0104 chemical sciences; 3. Good health; macrocycles; Acids, Heterocyclic; total synthesis; cycloaddition

Abstract The concise total syntheses of the bis(pyrroloindolines) (−)‐lansai B and (+)‐ nocardioazines A are reported. key pyrroloindoline building blocks rapidly prepared by enantioselective formal [3+2] cycloaddition reactions. macrocycle (+)‐nocardioazine is constructed an unusual intramolecular diketopiperazine formation.