Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform for Halogenated and Trifluoromethylated α‐Boryl Ketones

• DOI: 10.1002/ange.201604898
• Publication Date: 2016-07-22T06:13:10Z
• Authors: Wen‐Xin Lv; Yao‐Fu Zeng; Qingjiang Li; Yunyun Chen; Dong‐Hang Tan; Ling Yang; Honggen Wang
• Keywords: 01 natural sciences; 0104 chemical sciences

Abstract The synthesis of halogenated and trifluoromethylated α‐boryl ketones via a one‐pot oxidative difunctionalization alkenyl MIDA boronates is reported. These novel densely functionalized organoborons bearing synthetically functionally valuable carbonyl, halogen/CF 3 boronate moieties within the same molecule are challenging for chemist, but have great synthetic potential, as demonstrated by their applications in straightforward borylated furans. generality this reaction was extensively investigated. This attractive since starting materials, boronates, easily accessible.