Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes

• DOI: 10.1002/anie.201104391
• Publication Date: 2011-09-27T13:57:30Z
• Authors: Evelyn Zeiler; Nathalie Braun; Thomas Böttcher; Andreas Kastenmüller; Sevil Weinkauf; Stephan A. Sieber
• Keywords: ENCODE

The Clp proteolytic machinery has important functions in many bacteria such as L. monocytogenes. Some organisms encode for two uncharacterized ClpP isoforms. Vibralactone was used to study the activity and assembly of ClpP1 ClpP2 subunits a hetero-oligomeric complex. Electron microscopic images reveal that tetradecameric is made up stacked homoheptameric rings. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They available submitted by authors. Please note: publisher responsible content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.