A Sensitive Zinc‐Activated 129Xe MRI Probe

• DOI: 10.1002/anie.201109194
• Publication Date: 2012-03-12T14:33:05Z
• Authors: Naoko Kotera; Nawal Tassali; Estelle Léonce; Céline Boutin; Patrick Berthault; Thierry Brotin; Jean‐Pierre Dutasta; Léa Delacour; Ténin Traoré; David‐Alexandre B...; Frédéric Taran; Sylvie Coudert; Bernard Rousseau
• Keywords: Isotopes of zinc

Xenon capsule: A smart 129Xe NMR-based sensor of Zn2+ ions for magnetic resonance imaging (MRI) is proposed. The frequency xenon encapsulated in a cryptophane that bears nitrilotriacetic ligand moiety varies when are present solution (see picture). With hyper-polarized gas, such construct enables detection 100 nM zinc one batch, threshold 300 times lower than achieved with gadolinium chelates.