CO Cross‐Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols

• DOI: 10.1002/anie.201203460
• Publication Date: 2012-08-06T16:15:15Z
• Authors: Peter E. Maligres; Jing Li; Shane W. Krska; John D. Schreier; Izzat T. Raheem
• Keywords: Stereoisomerism; 01 natural sciences; Carbon; Catalysis; 0104 chemical sciences; Oxygen; Halogens; Heterocyclic Compounds; Alcohols; Copper; Palladium

A robust and general catalyst system facilitates the alkoxylation of activated heteroaryl halides with primary, secondary, select tertiary alcohols without need for an excess either coupling partner (see scheme). This displays broad functional-group tolerance excellent regioselectivity, is insensitive to order reagent addition. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note: The publisher responsible content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.