Investigation of RNA–Ligand Interactions by 19F NMR Spectroscopy Using Fluorinated Probes

• DOI: 10.1002/anie.201204083
• Publication Date: 2012-08-21T07:57:52Z
• Authors: Thomas Lombès; Roba Moumné; Valéry Larue; Elise Prost; Marjorie Catala; Thomas Lecourt; Frédéric Dardel; Laurent Micouin; Carine Tisné
• Keywords: Riboswitch

Spy swap: The interaction between an unlabeled RNA and ligands (red hexagon) can be monitored by 19F NMR spectroscopy using small fluorinated diamines (green star) as spy reporters (see scheme). This technique also enables the visualization of conformational capture a riboswitch its ligand. Detailed facts importance to specialist readers are published ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: publisher is responsible for content functionality any supporting information supplied Any queries (other than missing content) should directed corresponding author article.