Supramolecular Self‐Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF‐α siRNA against Systemic Inflammation

• DOI: 10.1002/anie.201209991
• Publication Date: 2013-04-22T20:09:26Z
• Authors: Lichen Yin; Ziyuan Song; Qiuhao Qu; Kyung Hoon Kim; Nan Zheng; Catherine Yao; Isthier Chaudhury; Haoyu Tang; Nathan P. Gabrielson; Fatih M. Uckun; Jianjun Cheng
• Keywords: Systemic administration

A functional package: Multifunctional supramolecular self-assembled nanoparticles (SSNPs) consist of a set rationally designed components that collectively facilitate efficient intestinal absorption siRNA and induce potent TNF-α silencing in macrophages. Single gavage SSNPs mice depletes systemic production at an dose as low 50 μg kg−1, thus protects from lipopolysaccharide-induced hepatic injury.