Rhodium‐Catalyzed Oxygenative Addition to Terminal Alkynes for the Synthesis of Esters, Amides, and Carboxylic Acids

• DOI: 10.1002/anie.201303669
• Publication Date: 2013-08-12T13:47:51Z
• Authors: Insu Kim; Chulbom Lee
• Keywords: 01 natural sciences; 3. Good health; 0104 chemical sciences

A gem of a couple: The title reaction terminal alkynes with O and N nucleophiles proceeds in the presence [{Rh(cod)Cl}2], P(4-FC6H4)3, 4-picoline N-oxide. Alcohols, amines, water add to give esters, amides, carboxylic acids, respectively. involves formation rhodium vinylidene, oxidation ketene by oxygen transfer, nucleophilic addition. As service our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: publisher is responsible content functionality any Any queries content) directed corresponding author article.