Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N‐Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan‐2‐ol

• DOI: 10.1002/anie.201702511
• Publication Date: 2017-04-24T08:55:46Z
• Authors: Eden Gaster; Sebastian Kozuch; Doron Pappo
• Keywords: Chemoselectivity; Autoxidation; Benzaldehyde

Abstract Efficient and highly selective catalytic conditions for the aerobic autoxidation of methylarenes to benzaldehydes, based on N ‐hydroxyphthalimide (NHPI) cobalt(II) acetate in 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP), were developed. The sustainable enable a multigram scale preparation benzaldehyde derivatives high efficiency with excellent chemoselectivity (up 99 % conversion 98 selectivity).