Cu‐Catalyzed Cross‐Dehydrogenative ortho‐Aminomethylation of Phenols

• DOI: 10.1002/anie.201804829
• Publication Date: 2018-06-22T07:42:51Z
• Authors: Congjun Yu; Frederic W. Patureau
• Keywords: Scope (computer science); Coupling reaction

Abstract A highly selective Cu II ‐catalyzed cross‐dehydrogenative ortho ‐aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp 2 )−C(sp 3 ) coupling products were obtained in moderate to excellent yields under mild reaction conditions and a broad substrate scope. radical mechanism proposed.