Nucleotide‐Selective Templated Self‐Assembly of Nanoreactors under Dissipative Conditions

• DOI: 10.1002/anie.202010199
• Publication Date: 2020-08-25T01:31:42Z
• Authors: Sushmitha Chandra...; Subhabrata Maiti; Ilaria Fortunati; Camilla Ferrante; Luca Gabrielli; Leonard J. Prins
• Keywords: Nanoreactor

Nature adopts complex chemical networks to finely tune biochemical processes. Indeed, small biomolecules play a key role in regulating the flux of metabolic pathways. Chemistry, which was traditionally focused on reactions simple mixtures, is dedicating increasing attention network reactivity highly synthetic systems, able display new kinetic phenomena. Herein, we show that addition monophosphate nucleosides mixture amphiphiles and reagents leads selective templated formation self-assembled structures, can accelerate reaction between two hydrophobic reactants. The correct matching nucleotide amphiphile head group fundamental for assemblies consequent up-regulation reaction. Transient stability nanoreactors obtained under dissipative conditions, driven by enzymatic dephosphorylation templating nucleotides. These results molecules modulating reactivity, selectively structures are up-regulate