Genetically Engineered Polypeptide Adhesive Coacervates for Surgical Applications

• DOI: 10.1002/anie.202100064
• Publication Date: 2021-04-22T21:31:43Z
• Authors: Jing Sun; Lingling Xiao; Bo Li; Kelu Zhao; Zili Wang; Yu Zhou; Chao Ma; Jingjing Li; Hongjie Zhang; Andreas Herrmann; Kai Liu
• Keywords: Coacervate; Biofouling; Azobenzene; Ex vivo

Adhesive hydrogels have been developed for wound healing applications. However, their adhesive performance is impaired dramatically due to high swelling on wet tissues. To tackle this challenge, we fabricated a new type of non-swelling protein underwater and in vivo In soft material, the electrostatic complexation between supercharged polypeptides with oppositely charged surfactants containing 3,4-dihydroxylphenylalanine or azobenzene moieties plays an important role formation ultra-strong coacervates. Remarkably, adhesion capability superior commercial cyanoacrylate when tested ambient conditions. Moreover, stronger than other reported protein-based adhesives environment. The ex experiments demonstrate persistent outstanding behaviors sealing healing.