Eco‐friendly synthesis of ZnO nanorods using Cycas pschannae plant extract with excellent photocatalytic, antioxidant, and anticancer nanomedicine for lung cancer treatment

• DOI: 10.1002/aoc.5511
• Publication Date: 2020-01-29T08:42:52Z
• Authors: Kattakgoundar Gov...; Saheb Ali; Gopalu Karunakaran; Mariyappan Kowsalya; Evgeny Kolesnikov; Mohan Prasanna Ra...
• Keywords: Nanorod; Viability assay; MTT assay

The tunable ZnO nanorods (NRs) are produced due to the phytochemicals present in Cycas pschannae leaves which act as reducing and stabilizing agents. confirmations of NRs were validated using different characterization techniques: X‐ray diffraction, Fourier transform infrared spectroscopy, Brunauer, Emmett Teller (BET), scanning electron microscopy–Energy Dispersive X‐Ray Analysis (EDX), UV–visible Raman transmission microscopy. show unique surface area low particle size. Photocatalytic activity was measured found be 50.75% at concentrations 78.33% high concentrations. antioxidant also showed promising results for their use free radical scavenging. In vitro toxicity studies zebrafish embryos performed evaluate toxic nature it obtained result confirmed its non‐toxic nature. addition, anticancer potential verified A549 lung cancer cell line. Cytotoxic assessments via 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide (XTT), 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT), neutral red uptake assays examine death cycle on cell. Dose‐dependent apoptosis necrosis by Lactate dehydrogenase (LDH) assay. It that induce Reactive oxygen species (ROS) inside (A549) cells intrinsic gene expression. Thus, based this research is evident an effective ecofriendly, nontoxic drug can synthesized C. leaf extract.