Diet supplement based on radiation‐modified chitosan and radiation‐synthesized polyvinylpyrrolidone microgels: Influence on the liver weight in rats fed a fat‐ and cholesterol‐rich diet

• DOI: 10.1002/app.26103
• Publication Date: 2007-04-10T17:09:31Z
• Authors: Renata Czechowska...; Piotr Ulański; Alicja K. Olejnik; Grażyna Nowicka; Bogumiła Panczenk...; Janusz M. Rosiak
• Keywords: Polyvinylpyrrolidone

Abstract A polymer‐based preparation (a chitosan–microgel called CHM), intended for use as a diet supplement reducing fat and cholesterol absorption from the digestive tract, was obtained by combination of chitosan reduced molecular weight with polyvinylpyrrolidone microgel in 1 : (w/w) ratio. Both components were ionizing radiation (controlled degradation solid state crosslinking polymerization neat vinylpyrrolidone). The component shown previous vitro studies to exhibit high fat‐binding capacity, whereas microgels, able swell about 40 times their original volume, serve stomach‐filling agents. influence CHM on body mass, liver other principal organs, serum levels triglycerides examined rats fed fat‐ cholesterol‐rich (FChD). It found that administered additive at 4% (2% chitosan) effectively prevented mass gain, accumulation liver, enlargement, which otherwise developed animals FChD only, main organs (heart, kidney, spleen, testicles, lungs) remained unaltered. also capable exerting this effect when already an atherosclerotic, overweight condition. No adverse effects observed during 10 weeks feeding CHM‐containing diet. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 105: 169–176,