Evaluation of developmental toxicity induced by anticholinesterase insecticide, diazinon in female rats

• DOI: 10.1002/bdrb.20322
• Publication Date: 2011-07-18T18:11:37Z
• Authors: Reda H. ElMazoudy; Azza A. Attia; Horeya S. AbdElGawad
• Keywords: Developmental toxicity; Cholinesterase

Abstract Developmental toxicities, including birth defects, are significant public health problems. This study was planned to assess the cholinergic and developmental potentials of diazinon that is widely used as an organophosphate insecticide. Pregnant female Sprague‐Dawley rats were given orally at doses 0, 1.9, 3.8, 7.6 mg/kg body weight (b.w.)/day on gestation days 6 15. Maternal brain acetylcholinesterase activities, measured day20, significantly decreased 3.8 b.w./day, but fetal activity not altered. evidenced by symptoms diarrhea, tremors, weakness, salivation, observed b.w./day dose groups. Net gravid uterine a b.w./day. No maternal effects apparent in 1.9 group. toxicity did induce fetotoxicity or teratogeneicity. However, resulted malformations addition animals. In conclusion, teratogenic disorders only outlined produced marked toxicity. Since morphologically related, they considered be secondary toxicity; hence, related cholinesterase inhibition. Birth Defects Res (Part B) 92:534–542, 2011. © 2011 Wiley Periodicals, Inc.