Imparting of Nearly Superparamagnetic Properties to Cryogel Scaffolds With Mesoporous MNPs for Magneto‐Sensitive Tissue Engineering Strategies

• DOI: 10.1002/bip.23623
• Publication Date: 2024-08-19T12:53:57Z
• Authors: Didem Demir; Fatma Ulusal; Hasan Ulusal; Seda Ceylan; Sibel Dağlı; Nalan Özdemir; Mehmet Tarakçıoğlu
• Keywords: Gelatin; Superparamagnetism; Biocompatibility; Biopolymer

ABSTRACT This work reports the assembly of mesoporous iron oxide nanoparticles (meso‐MNPs) with cryogel scaffolds composed chitosan and gelatin. Meso‐MNPs a particle size ranging from 2 50 nm, surface area 140.52 m g −1 , pore volume 0.27 cm 3 were synthesized on porous SiO template in presence PEG 6000 followed by leaching . Different ratios meso‐MNPs successfully incorporated into chitosan:gelatin cryogels up to an amount equivalent entire polymer. The morphological structure physicochemical properties directly affected MNPs. VSM curves showed that all composite could be magnetized applying magnetic field. In context safety for use biomedicine, it is important note values are below exposure limit static fields, according cytotoxicity data, containing nontoxicity cell viability 150% 275%. addition, microbial analysis gram‐negative gram‐positive bacteria exhibited activity against these bacteria.