Prediction of early response to overall treatment for schizophrenia: A functional magnetic resonance imaging study

• DOI: 10.1002/brb3.1211
• Publication Date: 2019-01-31T04:35:22Z
• Authors: Long‐Biao Cui; Min Cai; Xing‐Rui Wang; Yuan‐Qiang Zhu; Liu‐Xian Wang; Yi‐Bin Xi; Hua‐Ning Wang; Xia Zhu; Hong Yin
• Keywords: Inferior parietal lobule; Postcentral gyrus

Abstract Introduction Treatment response at an early stage of schizophrenia is considerable value with regard to future management the disorder; however, there are currently no biomarkers that can inform physicians about likelihood response. Objects We aim develop and validate regional brain activity derived from functional magnetic resonance imaging (fMRI) as a potential signature predict treatment in schizophrenia. Methods Amplitude low‐frequency fluctuation (ALFF) was measured start first/single episode resulting hospitalization. Inpatients were included principal dataset ( n = 79) replication 44). Two groups healthy controls 87; 106) also recruited for each dataset. The clinical assessed discharge hospital. predictive capacity normalized ALFF patients by controls, ratio , evaluated based on diagnostic tests correlates. Results In dataset, responders exhibited increased baseline left postcentral gyrus/inferior parietal lobule relative non‐responders. before significantly higher than non‐responders p < 0.001). area under receiver operating characteristic curve 0.746 distinguish non‐responders, sensitivity, specificity, accuracy 72.7%, 68.6%, 70.9%, respectively. Similar results found independent Conclusions Baseline seems be This study shows psycho‐neuroimaging holds promise influencing