Chemical Constituents with Ferroptosis Inhibitory Activity of the Deep‐Sea‐Derived Penicillium paxilli

• DOI: 10.1002/cbdv.202500540
• Publication Date: 2025-03-19T16:53:31Z
• Authors: Zhe‐Wen Chen; Yuan Wang; Rong Chao; Tai‐Zong Wu; Tian‐Hua Zhong; Xian‐Wen Yang; Bin Wang

ABSTRACTA rare tri‐nor‐non‐paspaline indole diterpenoid (penpaxin A, 1), a new 1,3‐dioxolane derivative (penpaxin B, 9), and 19 known compounds (2–8 and 10–21) were isolated from the deep‐sea‐derived Penicillium paxilli MCCC 3A01133. The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and ORD data. 3‐Deoxo‐4b‐deoxypaxilline (5) and paspaline (7) exhibited potent inhibition on RSL3‐induced ferroptosis with the EC50 values of 2.88 and 0.21 µM, respectively.