Impact of Post Percutaneous Coronary Intervention Fractional Flow Reserve on 5‐Year Clinical Outcomes (The FFR SEARCH Study)

• DOI: 10.1002/ccd.31493
• Publication Date: 2025-03-13T06:39:42Z
• Authors: Frederik T. W. Gr...; Annemieke C. Zied...; Tara Neleman; Alessandra Scoccia; Jari A. van der Eijk; Kaneshka Masdjedi; Laurens J. C. van...; Wijnand K. den De...; Jeroen M. Wilschut; Isabella Kardys; Paul Cummins; Roberto Diletti; Nicolas M. Van Mi...; Joost Daemen
• Keywords: Fractional Flow Reserve

ABSTRACT Background Fractional flow reserve (FFR) following percutaneous coronary intervention (PCI) can be used to evaluate procedural success and guide stent optimization. Several studies have demonstrated that lower FFR after implantation is associated with increased adverse event rates up 2 years. However, the impact of post‐PCI on very long‐term clinical outcome remains unknown. Methods The SEARCH study a single‐center, prospective, observational including consecutive patients undergoing PCI from 2016 2017. measurement was performed angiographically successful using dedicated microcatheter. primary endpoint target vessel failure (TVF) at 5 years, composite cardiovascular death, myocardial infarction revascularization. optimal cutoff value predict 5‐year TVF determined based maximum log‐rank statistic. Results Post‐PCI measurements were successfully in 959 patients. Mean age 64.0 ± 11.9 72.5% male 33.6% presented ST‐segment elevation infarction. left anterior descending artery 53.5%. ≤ 0.90. occurred 18.4% 0.90 versus 11.6% > (adjusted HR 1.65 (95% CI 1.11–2.48, p = 0.014)). Conclusions This large prospective demonstrates higher rate