The comparative effects of telmisartan and ramipril on P-wave dispersion in hypertensive patients: A randomized clinical study

• DOI: 10.1002/clc.4960280609
• Publication Date: 2007-06-28T05:09:50Z
• Authors: Turgay Celik; Atila Iyisoy; Hurkan Kursaklioglu; M. Ilker Yilmaz; Sedat Kose; Selim Kilic; Basri Amasyali; Sait Demirkol; Ersoy Isik
• Keywords: Ramipril; Telmisartan; Hypertensive crisis

Background: Prolongation of P-wave times and increase dispersion (PWD) were shown to be independent predictors atrial fibrillation (AF). Angiotensin II receptor blockers (AARBs) angiotensin-converting enzyme inhibitors (ACEIs) have beneficial effects on conduction times. However, there are not enough data about the comparative those drugs onPWD. Hypothesis: We aimed compare telmisartan ramipril PWD after 6-month treatment in hypertensive patients. Methods: In all, 100 newly diagnosed patients enrolled study randomly assigned two groups. Group 1 2 each consisted 50 patients, taking daily doses 80 mg 10 ramipril, respectively. Twelve-lead surface electrocardiograms (ECG) recorded from all before drug therapy. The duration (Pdur) measurements calculated 12-lead ECG. Results: When pretreatment P maximum values compared with post-treatment values, a statistically significant decrease was found both groups 6 months (Group 2; p < 0.001 for Pmaximum). Pmaximum significantly lower than period (p = 0.01 PWD; 0.008 Conclusions: Telmisartan has much greater lowering effect ramipril. This finding may important prevention AF