Design, Synthesis, and Biological Evaluation of Levoglucosenone‐Derived Ras Activation Inhibitors

• DOI: 10.1002/cmdc.200800416
• Publication Date: 2009-02-18T07:27:35Z
• Authors: Christian Müller; Maria Antonia Gom...; Dario Ballinari; Sonia Colombo; Alessandro Bitto; Enzo Martegani; Cristina Airoldi; Anske Stephanie v...; Matthias Stein; Jörg Weiser; Carlo Battistini; Francesco Peri
• Keywords: Tricyclic

Abstract A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone‐derived scaffold with aromatic moieties. Some members the show in vitro inhibitory activity toward nucleotide exchange process on and are toxic to some human cancer cell lines. magnified image