A Facile Synthesis of Novel Bis‐(indolyl)‐1,3,4‐oxadiazoles as Potent Cytotoxic Agents

• DOI: 10.1002/cmdc.201200363
• Publication Date: 2012-09-20T13:39:12Z
• Authors: Dalip Kumar; V. Arun; N. Maruthi Kumar; Glen Acosta; Brett Noel; Kavita Shah
• Keywords: Iodobenzene

A recipe for potency: novel series of bis(indolyl)-1,3,4-oxadiazoles was prepared from the corresponding hydrazide-hydrazones via iodobenzene diacetate-promoted oxidative cyclization. Evaluation against a panel human cancer cell lines revealed that some derivatives possess potent cytotoxicity with tunable selectivity different types. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note: The publisher is responsible content functionality any supporting information supplied Any queries (other than missing content) should be directed author article.