Mesoporous Polydopamine‐Based Nanovehicles as a Versatile Drug Loading Platform to Enable Tumor‐Sufficient Synergistic Therapy

• DOI: 10.1002/cmdc.202200360
• Publication Date: 2022-08-24T12:06:08Z
• Authors: Suhua Jiang; Fukai Zhu; Xiaoxuan Ji; Jiaqi Li; Haina Tian; Bingli Wang; Luanmei Lu; Peiyuan Wang
• Keywords: Indoles; Polymers; Pyridines; Diazonium Compounds; 02 engineering and technology; Phototherapy; 3. Good health; Drug Liberation; Mice; Drug Delivery Systems; Pharmaceutical Preparations; Doxorubicin; Neoplasms; Animals; Humans; Nanoparticles; 0210 nano-technology

The combination of photothermal therapy and chemotherapy are developing as a promising clinical strategy but it urgently needs the high exploration intelligent multifunctional drug delivery nanovectors. In this paper, we used versatile method to construct mesoporous polydopamine nanovehicles (MPDA) with dendritic mesopores loaded chemotherapeutic drug, Doxorubicin (MPDA@DOX). monodisperse nanoagents spherical size ∼160 nm pore approximately 10 nm. MPDA could efficiently DOX π-π stacking interaction acts potent agents. Importantly, MPDA@DOX preferentially internalized by cancerous cells, then bursting release local hyperthermia generation were observed in conditions representative cytoplasm tumor cells that highly synergistic cell killing effect found under 808 laser irradiation. fluorescent imaging results human breast bearing murine model evidenced platform have excellent precise targeting vivo ablation experiment further revealed showed markedly eradicated growth capability exposure. Therefore, work provided fascinating based on biocompatible system for malignant tumors eradication via therapy.