Small‐Molecule Endoplasmic Reticulum Stress Inducer Triggers Apoptosis in Cancer Cells

• DOI: 10.1002/cmdc.202300433
• Publication Date: 2023-11-15T18:27:16Z
• Authors: Jaypalsing Ingle; Anjana Tirkey; Shalini Pandey; Sudipta Basu
• Keywords: HeLa

Abstract Endoplasmic reticulum (ER) is highly critical for the sub‐cellular protein synthesis, post‐translational modifications and myriads of signalling pathways to maintain cellular homeostasis. Consequently, dysregulation in ER functions leads stress different pathological situations including cancer. Hence, exploring small molecules induce emerged as one unorthodox strategies future cancer therapeutics. However, development targeted novel remains elusive due dearth targeting moieties. Herein we have synthesized a library 3‐methoxy‐pyrrole‐enamine through concise strategy. Screening this cervical (HeLa), colon (HCT‐116), breast (MCF7) lung (A549) cells identified molecule which localized into HeLa within 3 h, induced increased expression markers (CHOP, IRE1α, PERK, BiP Cas‐12) triggered programmed cell death (apoptosis) leading remarkable killing. This can be explored further tool understand chemical biology towards