Muscle radiodensity and mortality in patients with colorectal cancer

• DOI: 10.1002/cncr.31405
• Publication Date: 2018-05-24T20:04:25Z
• Authors: Candyce H. Kroenke; Carla M. Prado; Jeffrey A. Meyerh...; Erin K. Weltzien; Jingjie Xiao; Elizabeth M. Cesp...; Bette J. Caan
• Keywords: Radiodensity

Low skeletal muscle radiodensity (SMD) is related to higher mortality in several cancers, but the association with colorectal cancer (CRC) prognosis unclear.This observational study included 3262 men and women from Kaiser Permanente Northern California population diagnosed between 2006 2011 AJCC stages I III CRC. The authors evaluated hazard ratios (HRs) of low SMD for all-cause CRC-specific mortality, assessed by computed tomography using optimal stratification, compared patients normal SMD. They also cross-classification categories versus mass (MM) outcomes.The median follow-up was 6.9 years. Optimal stratification cutpoints were 32.5 35.5 men. In multivariate-adjusted analyses, among CRC, those demonstrated overall (HR, 1.61; 95% confidence interval [95% CI], 1.36-1.90) 1.74; CI, 1.38-2.21) when levels. Patients MM (ie, sarcopenia) found have highest 2.02; 1.65-2.47) 2.54; 1.91-3.37) rates.In elevated risks disease-specific independent or adiposity. Clinical practice should incorporate body composition measures into evaluation health status Cancer 2018;124:3008-15. © 2018 American Society.