Suzuki–Miyaura Coupling of Aryl Sulfonates with Arylboronic Acids Using a Morpholine–Pd(OAc)2 Catalyst System

• DOI: 10.1002/ejoc.201402120
• Publication Date: 2014-05-13T11:26:46Z
• Authors: Taichi Abe; Takashi Mino; Kohei Watanabe; Fumitoshi Yagishita; Masami Sakamoto
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractWe report a new catalyst system, a morpholine–Pd(OAc)2 complex, for Suzuki–Miyaura coupling of aryl tosylates or mesylates with arylboronic acids to give biaryl compounds. The morpholine–Pd(OAc)2 catalyst system is proposed to be a precursor of the catalytically active species in the coupling reaction. Aryl chlorides and aryl triflates can also be used in this coupling reaction. Altogether, 22 biaryl compounds were obtained using this catalyst system.