Convenient Approach to 10‐ and 11‐Membered Azalactams

• DOI: 10.1002/ejoc.202300142
• Publication Date: 2023-04-17T18:25:31Z
• Authors: Viacheslav Lysenko; Kostiantyn Shvydenko; Kostiantyn Nazarenko; Svitlana Shishkina; Eduard Rusanov; Aleksandr Kostyuk
• Keywords: Amidine; Cleavage (geology)

Abstract A convenient method for the synthesis of 10‐ and 11‐membered azalactams via reductive cleavage bicyclic systems featuring an amidine fragment was studied. It found that ring‐expansion reaction dihydropyrimidones depends on ring size saturated fragment, substituents in pyrimidone core conditions. new efficient medium by quaternary salts annulated proposed as well. The obtained with a secondary amine function were used heteroaromatic systems.