K2S2O8‐Mediated C‐3 Formylation of Imidazopyridines Using Glyoxylic Acid

• DOI: 10.1002/ejoc.202300829
• Publication Date: 2023-09-26T15:05:00Z
• Authors: Harish K. Indurthi; Samarpita Das; Pallavi Saha; Deepak K. Sharma
• Keywords: Glyoxylic acid; Formylation; Functional group; Coupling reaction

Abstract A metal‐free formylation of imidazopyridines by direct decarboxylative cross‐coupling glyoxylic acid in presence K 2 S O 8 as oxidant under mild and neutral conditions is described. This reaction features a broad substrate scope, good functional group tolerance, generates products yields between 68–85 %. The translational capacity the from laboratory methodology to gram‐scale synthesis has also been ensured. involvement radical pathway demonstrated trapping experiments with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) 2,6‐di‐tert‐butyl‐4‐methylphenol (BHT).