Genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro

• DOI: 10.1002/em.20587
• Publication Date: 2010-04-29T14:29:35Z
• Authors: Antonella Di Sotto; Gabriela Mazzanti; Fabio Carbone; Patrizia Hrelia; Francesca Maffei
• Keywords: Linalyl acetate; Lavender oil; Nerolidol; Lavandula

Abstract The potential genotoxicity of lavender essential oil and its major components, linalool, linalyl acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. In range non‐toxic concentrations (0.5–100 μg/ml), acetate increased frequency micronuclei significantly concentration‐dependent manner; did so only at highest concentration tested, whereas linalool devoid genotoxicity. None tested substances led to an increase nucleoplasmic bridges or nuclear buds frequency. These findings suggest that mutagenic activity can be related presence which seems have a profile aneugenic agent. Environ. Mol. Mutagen. 52:69–71, 2011. © 2010 Wiley‐Liss, Inc.