TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer

• DOI: 10.1002/gcc.20755
• Publication Date: 2010-02-05T18:32:11Z
• Authors: Toshiyuki Okada; Yutaka Suehiro; Koji Ueno; Shoko Mitomori; Sayaka Kaneko; Mitsuaki Nishioka; Naoko Okayama; Kouhei Sakai; Shingo Higaki; Shoichi Hazama; Hiroshi Hirata; Isao Sakaida; Masaaki Oka; Yuji Hinoda
• Keywords: Colorectal adenoma; Clinical Significance

Abstract Although growing evidence demonstrates that TWIST1 is an interesting tumor biomarker, little known about the clinical significance of expression and methylation in human primary colorectal cancer. In this study, we examined association with clinicopathologic features tumors. Primary cancer (CRC) specimens from 319 patients, corresponding normal nontumorous mucosa 251 patients cancer, adenomas 189 were used. Methylation levels compared features. The level was higher adenoma than mucosa. Elevated mRNA CRC as well associated unfavorable outcomes. There no correlation between expression. Our results suggest may be a useful biomarker for screening addition, possible molecular marker predicting outcome CRC. Confirmatory studies using independent data sets are needed to confirm our findings. © 2010 Wiley‐Liss, Inc.